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Starting TUKYSA® (tucatinib)

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How to take the TUKYSA regimen*

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TUKYSA is part of a treatment plan that includes trastuzumab and capecitabine

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Take the TUKYSA regimen* exactly as your healthcare provider tells you. Your healthcare provider may change your dose of TUKYSA if needed. Talk to your care team if you have any questions about TUKYSA or your treatment plan.


*TUKYSA regimen: TUKYSA, trastuzumab, capecitabine

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Take TUKYSA orally 2x a day

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  • Take each dose twice a day, about 12 hours apart at the same times every day, with or without food
  • Swallow tablets whole. Do not chew, crush, or split the tablets. Do not take TUKYSA tablets if they are broken, cracked, or damaged
  • If you vomit or miss a dose of TUKYSA, take your next dose at your regular time
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Receive trastuzumab infusion every 21 days

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  • Receive trastuzumab at your healthcare provider’s office or infusion center on Day 1, and again every 21 days
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Take capecitabine 2x a day on days 1-14

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  • Take orally, twice daily, within 30 minutes after a meal
  • TUKYSA and capecitabine can be taken at the same time
  • Take capecitabine for 14 days, with a 7-day break before starting again
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TUKYSA (tucatinib) treatment tracker
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Keeping your treatment on track matters

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Download PDF

Explore more resources

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Specialty pharmacy services

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If TUKYSA is prescribed, it may be sent to you by a specialty pharmacy. There are many specialty pharmacies that understand the unique needs of people living with cancer.

Learn more about ways your specialty pharmacy can support you.

Determine your prescription coverage

Your specialty pharmacy will contact your insurance carrier to determine your prescription coverage. If coverage has been confirmed with your insurance, your specialty pharmacy will call you to coordinate how you’ll receive TUKYSA and to collect any additional information needed.

Send TUKYSA to you

Your specialty pharmacy will send your medication to your home, office, or other location of your choice. Someone will need to be at the delivery location to receive the package. Your shipping address, insurance coverage, and financial responsibility must be confirmed each time your prescription is filled.

Offer additional support

A dedicated team from your specialty pharmacy may connect with you regularly to:

  • Help you understand and navigate your prescription coverage
  • Answer questions about treatment or refills
  • Guide you to education, information, and inspiration specific to your treatment journey
  • Update your healthcare team about your treatment experience
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Calls from your specialty pharmacy are important.
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They may call you at least 7 days before receiving your prescription.

Your specialty pharmacy may leave a voicemail, but because of privacy laws, they may not provide a lot of detail in their message. Keep in mind that these calls may come from an 800 number, the specific area code of your specialty pharmacy, or a blocked, unavailable, or unknown number on your caller ID.
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Help finding financial support

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Pfizer Oncology Together™ will help you find potential financial assistance options for your prescribed Pfizer Oncology medicine, regardless of your insurance coverage. This applies to patients who are eligible and cannot afford to pay for their medicine.
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Commercially Insured

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Resources for eligible patients with commercial, private, employer, or state health insurance marketplace coverage:

  • Co-pay assistance: Eligible, commercially insured patients may pay as little as $0 per month for their Pfizer Oncology treatment. Limits, terms, and conditions apply.† Patients may receive up to $10,600 for TUKYSA and $6,000 for capecitabine in savings annually
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Join the co-pay savings program
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†Patients are not eligible to use this card if they are enrolled in a state or federally funded insurance program, including but not limited to Medicare, Medicaid, TRICARE, Veterans Affairs health care, a state prescription drug assistance program, or the Government Health Insurance Plan available in Puerto Rico.
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Medicare/Government Insured

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Help identifying resources for eligible patients with Medicare/Medicare Part D, Medicaid, or other government insurance plans who express a financial need:

  • We can assist patients with searching for financial support from alternate funding resources, which may include financial assistance through Extra Help, a Medicare Part D Low-Income Subsidy (LIS) program
  • If support from alternate funding resources or Medicare Extra Help is not available, Pfizer Oncology Together will see if patients are eligible for the Pfizer Patient Assistance Program,† which can provide prescribed Pfizer Oncology medicines for free
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†The Pfizer Patient Assistance Program is a joint program of Pfizer Inc. and the Pfizer Patient Assistance Foundation™. Free medicines from Pfizer are provided through the Pfizer Patient Assistance Foundation™. The Pfizer Patient Assistance Foundation™ is a separate legal entity from Pfizer Inc. with distinct legal restrictions.
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Uninsured

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Help identifying resources for eligible patients without any form of healthcare coverage:

  • We can check patient eligibility for Medicaid and help them understand how to apply
  • Patients who do not qualify for Medicaid may receive free medicine through the Pfizer Patient Assistance Program.‡ Patients must be eligible and reapply as needed
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‡The Pfizer Patient Assistance Program is a joint program of Pfizer Inc. and the Pfizer Patient Assistance Foundation™. Free medicines from Pfizer are provided through the Pfizer Patient Assistance Foundation™. The Pfizer Patient Assistance Foundation™ is a separate legal entity from Pfizer Inc. with distinct legal restrictions.
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Looking for support? We’ve got you covered

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Visit PfizerOncologyTogether.com