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TUKYSA Will be Sent to You by a Specialty Pharmacy

A Specialty Pharmacy understands the unique needs of people living with cancer. Specialty Pharmacies also fill prescriptions for medications that may not be available at your local pharmacy.

In most cases, your TUKYSA (tucatinib) prescriptions will be filled in 1 of the following ways:

  • Your healthcare provider may send your prescriptions to a Specialty Pharmacy; or
  • There may be a pharmacy at your healthcare provider's office or hospital that can fill your prescriptions for pick-up or delivery to your home

Your TUKYSA and capecitabine may come from two different pharmacies. If you have any challenges in coordination of care or scheduling deliveries, Seagen has dedicated staff, Seagen Secure, to help support you in obtaining your medicines.

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Your Specialty Pharmacy Will Determine Prescription Coverage for You

  • Your Specialty Pharmacy will work with your healthcare provider’s office to determine coverage for your TUKYSA (tucatinib) prescription
  • Once coverage has been confirmed, your Specialty Pharmacy will call you to coordinate the shipment of TUKYSA and collect any additional information needed
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Your Medication can be Sent to Your Home, Office, or Other Location of Your Choice

  • Your Specialty Pharmacy will need to ensure that someone will be at the delivery location to receive the package
  • Your shipping address, insurance coverage, and financial responsibility must be confirmed each time your prescription is filled
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Calls From Your Specialty Pharmacy are Important                              

  • Keep in mind that these calls may come from an “800” number, the specific area code of your Specialty Pharmacy, or a “Blocked” or “Unavailable/Unknown Caller” on your caller ID
  • The Specialty Pharmacy will leave a voicemail asking you to return their call, but because of privacy laws, they may not provide a lot of detail regarding the reason for their call
  • Your Specialty Pharmacy will call you at least 7 days before refilling your prescription--and you can also call to ask about prescription refills
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Through Your Specialty Pharmacy, You Will Also be Connected With a Dedicated Nurse Who Can:

  • Offer support
  • Answer questions about treatment
  • Guide you to resource

Your dedicated nurse will call on a regular basis when first starting treatment and will update your healthcare team about your treatment experience.

Seagen Secure Patient Assistance Program

Seagen Secure®                                                                                                         

Seagen Secure® can help you understand your insurance coverage and connect you with resources and support services to assist with access to TUKYSA. Their comprehensive support offerings include a commercial out-of-pocket assistance program and patient assistance program to those who qualify.

To learn more:

Important Safety Information

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What are the possible side effects of TUKYSA?

TUKYSA may cause serious side effects, including:

  • Diarrhea (watery, loose, or frequent stools) is common and can sometimes be severe. Tell your healthcare provider if you have a change in your bowel movements or severe diarrhea. Severe diarrhea can cause a loss of too much body fluid (dehydration), low blood pressure, kidney problems, and death. Your healthcare provider may prescribe medicines to treat your diarrhea during treatment with TUKYSA.
  • Liver Problems, including severe cases. Your healthcare provider will test your blood to check your liver function before starting and every 3 weeks during treatment with TUKYSA, or as needed. Tell your healthcare provider right away if you have any signs and symptoms of liver problems including itching, yellowing of the skin or eyes, dark or brown urine (tea-colored), pain or discomfort in the right upper stomach area (abdomen), feeling very tired, decreased appetite, or bleeding or bruising more easily than normal.

The most common side effects of TUKYSA:

  • diarrhea
  • rash, redness, pain, swelling, or blisters on the palms of your hands or soles of your feet
  • nausea
  • tiredness
  • increased liver function blood tests
  • vomiting
  • mouth sores (stomatitis)
  • decreased appetite
  • stomach-area (abdomen) pain
  • headache
  • a low number of red blood cells (anemia)
  • rash

Your healthcare provider may change your dose of TUKYSA, temporarily stop, or permanently stop treatment with TUKYSA if you have certain side effects.

TUKYSA may cause fertility problems in males and females, which may affect the ability to have children. Talk to your healthcare provider if you have concerns about fertility.

These are not all the possible side effects of TUKYSA. Discuss side effects with your healthcare provider. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit or call 1-800-FDA-1088.

What should I tell my healthcare provider before taking TUKYSA?

Before taking TUKYSA, tell your healthcare provider about all of your medical conditions, including if you:

  • have liver problems.
  • are pregnant or plan to get pregnant. TUKYSA can harm your unborn baby.
    Females who are able to become pregnant: Your healthcare provider will do a pregnancy test before you start taking TUKYSA. Use effective birth control (contraception) during TUKYSA treatment and for at least 1 week after the last dose of TUKYSA. Tell your healthcare provider right away if you become pregnant or think you may be pregnant during treatment with TUKYSA.

    Males with a female partner who can get pregnant:
    Use effective birth control during TUKYSA treatment and for at least 1 week after the last dose of TUKYSA.
  • are breastfeeding (nursing) or plan to breastfeed. Do not breastfeed during treatment with TUKYSA and for at least 1 week after the last dose of TUKYSA.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. TUKYSA may affect the way your other medicines work, and other medicines may affect the way TUKYSA works. Keep a list of all the medicines you take and show it to your healthcare provider and pharmacist every time you get a new medicine.


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What is TUKYSA?

TUKYSA is a prescription medicine used with the medicines trastuzumab and capecitabine to treat adults with human epidermal growth factor receptor-2 (HER2) positive breast cancer that has spread to other parts of the body such as the brain (metastatic), or that cannot be removed by surgery, and who have received one or more anti-HER2 breast cancer treatments.

It is not known if TUKYSA is safe and effective in children.

Please see Important Facts about TUKYSA.