Resources & support
Downloadable materials
Helpful materials to support you throughout treatment
TUKYSA® (tucatinib) brochure
Guides you through what you may expect from the TUKYSA treatment plan, including how it works, how it may help you, and possible side effects.
Treatment Tracker
Explains how to take TUKYSA, helps keep track of your dosing, and gives you space to take notes on how you are feeling.
Download
Share your experience
Gives you information on how to share your story and personal experience with TUKYSA to inform, encourage, and inspire others.
Download
FAQs
More calendar pages
Important Facts
Provides a brief summary of important information about TUKYSA, including what it's for, how to take it, and possible side effects it may cause.
Frequently asked questions (FAQs)
What is TUKYSA?
TUKYSA is used with the medicines trastuzumab and capecitabine if your cancer has spread to other parts of the body such as the brain (metastatic) or cannot be removed by surgery and you have received one or more anti-HER2 breast cancer treatments.
It is not known if TUKYSA is safe and effective in children.
Could TUKYSA be right for me?
TUKYSA was studied in 612 people with HER2+ metastatic breast cancer that had spread (metastasized) to other parts of the body, in a clinical trial called HER2CLIMB. These people had been treated before with Herceptin® (trastuzumab), Perjeta® (pertuzumab), and Kadcyla® (ado-trastuzumab emtansine).
In HER2CLIMB, people were given either:
- TUKYSA + trastuzumab + Xeloda® (capecitabine)
- Placebo + trastuzumab + capecitabine
What are the potential benefits of treatment with TUKYSA?
TUKYSA offers another chance at treating HER2+ metastatic breast cancer. In HER2CLIMB, treatment with TUKYSA, trastuzumab, and capecitabine was shown to:
- Offer more time without the cancer growing or spreading (median* time people lived without cancer progression was 7.8 months with TUKYSA along with trastuzumab and capecitabine versus 5.6 months with trastuzumab and capecitabine alone)
- Help people live longer (median* overall survival was 21.9 months with TUKYSA along with trastuzumab and capecitabine versus 17.4 months with trastuzumab and capecitabine alone)
*Median: The midpoint of a set of numbers, with half of the values below the median and half above it.
What are the possible side effects of TUKYSA?
The most common side effects of TUKYSA in combination with trastuzumab and capecitabine in adults with HER2-positive breast cancer include:
- diarrhea
- rash, redness, pain, swelling, or blisters on the palms of your hands or soles of your feet
- nausea
- increased liver function blood tests
- vomiting
- mouth sores (stomatitis)
- decreased appetite
- a low number of red blood cells (anemia)
- rash
Fatal adverse reactions occurred in 2% of patients who received TUKYSA. These are not all the possible side effects of TUKYSA, and you may also get side effects from the other medicines taken with TUKYSA. Talk to your healthcare provider about any side effects.
Has TUKYSA been evaluated in people with HER2+ metastatic breast cancer that has spread to the brain?
Yes. 48% of all people in HER2CLIMB (291 out of 612) had brain metastases when they entered the study.
- Among the people with brain metastases:
- 60% had active brain metastases, which means they were growing or spreading
- 40% had stable brain metastases, which means they were not growing or spreading
- In this population of people with brain metastases, treatment with TUKYSA, trastuzumab, and capecitabine offered more time without the cancer growing or spreading (median* time people lived without cancer progression was 7.6 months with TUKYSA along with trastuzumab and capecitabine compared to 5.4 months with placebo, trastuzumab, and capecitabine)
*Median: The midpoint of a set of numbers, with half of the values below the median and half above it.
How do I take TUKYSA?
- TUKYSA is an oral treatment
- Take TUKYSA exactly as your healthcare provider tells you
- Take each dose twice a day, about 12 hours apart at the same times every day, with or without food
- Swallow tablets whole. Do not chew, crush, or split the tablets. Do not take TUKYSA tablets if they are broken, cracked, or damaged
- If you vomit or miss a dose of TUKYSA, take your next dose at your regular time
Do I need tests with TUKYSA?
If you are a female who can become pregnant, your healthcare provider will do a pregnancy test before starting TUKYSA.
How will I receive TUKYSA?
TUKYSA can be sent to you by a specialty pharmacy that has unique experience in oncology and is trained in helping people who are living with cancer to manage their treatment. Your specialty pharmacy offers ongoing support by:
- Coordinating your treatment plan and collaborating with your healthcare provider
- Working with your insurance provider to determine your prescription coverage
- Answering your questions about treatment
- Guiding you to resources
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