Indication: TUKYSA is a prescription medicine used with the medicines trastuzumab and capecitabine to treat adults with human epidermal growth factor receptor-2 (HER2) positive breast cancer that has spread to other parts of the body such as the brain (metastatic), or that cannot be removed by surgery, and who have received one or more anti-HER2 breast cancer treatments. It is not known if TUKYSA is safe and effective in children.

TUKYSA™ (tucatinib) tablets
TUKYSA™ (tucatinib) tablets
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NOW APPROVED

TUKYSA Offered More Time

TUKYSA, along with HERCEPTIN® (trastuzumab) and XELODA® (capecitabine) offers another chance at treating HER2+ metastatic breast cancer.

In the clinical study, TUKYSA*:

  • Offered more time without cancer growing and spreading (median time without progression was 7.8 months with TUKYSA* vs 5.6 months with trastuzumab and capecitabine alone)
  • Helped people live longer (median overall survival was 21.9 months with TUKYSA* vs 17.4 months with trastuzumab and capecitabine alone)
What is TUKYSA? Link Out Icon
Median: The middle number in a group of numbers arranged from lowest to highest; also called the midpoint.

*TUKYSA is part of a treatment plan that includes trastuzumab and capecitabine.

Possible Side Effects

As with all cancer treatments, side effects are possible.

The most common side effects included diarrhea; rash, redness, pain, swelling, or blisters on the palms of your hands or soles of your feet; nausea; and tiredness. These are not all the possible side effects of TUKYSA, and you may also get side effects from the other medicines taken with TUKYSA.

Here’s what you can expect from treatment
Side effects Link Out Icon

Another Chance at Treating Your Cancer

TUKYSA, along with trastuzumab and capecitabine, is a new, targeted oral treatment option. It's for people with HER2+ metastatic breast cancer who have received at least 1 other treatment in the metastatic setting, such as trastuzumab, PERJETA® (pertuzumab), or KADCYLA® (trastuzumab emtansine).

Learn about the TUKYSA clinical study
About HER2CLIMB Link Out Icon

Select Safety Information

What are the possible side effects of TUKYSA?
TUKYSA may cause serious side effects, including:
  • Diarrhea (watery, loose, or frequent stools) is common and can sometimes be severe. Tell your healthcare provider if you have a change in your bowel movements or severe diarrhea. Severe diarrhea can cause a loss of too much body fluid (dehydration), low blood pressure, kidney problems, and death. Your healthcare provider may prescribe medicines to treat your diarrhea during treatment with TUKYSA.
  • Liver Problems, including severe cases. Your healthcare provider will test your blood to check your liver function before starting and every 3 weeks during treatment with TUKYSA, or as needed. Tell your healthcare provider right away if you have any signs and symptoms of liver problems including itching, yellowing of the skin or eyes, dark or brown urine (tea-colored), pain or discomfort in the right upper stomach area (abdomen), feeling very tired, decreased appetite, or bleeding or bruising more easily than normal.

Select Safety Information

What are the possible side effects of TUKYSA?
TUKYSA may cause serious side effects, including:
  • Diarrhea (watery, loose, or frequent stools) is common and can sometimes be severe. Tell your healthcare provider if you have a change in your bowel movements or severe diarrhea. Severe diarrhea can cause a loss of too much body fluid (dehydration), low blood pressure, kidney problems, and death. Your healthcare provider may prescribe medicines to treat your diarrhea during treatment with TUKYSA.
  • Liver Problems, including severe cases. Your healthcare provider will test your blood to check your liver function before starting and every 3 weeks during treatment with TUKYSA, or as needed. Tell your healthcare provider right away if you have any signs and symptoms of liver problems including itching, yellowing of the skin or eyes, dark or brown urine (tea-colored), pain or discomfort in the right upper stomach area (abdomen), feeling very tired, decreased appetite, or bleeding or bruising more easily than normal.

Ready to Learn More About TUKYSA?

Get answers to frequently asked questions about treatment
TUKYSA FAQs Link Out Icon

Our Thanks and Gratitude

Seattle Genetics would like to extend our sincere gratitude and deepest appreciation to the people living with HER2+ metastatic breast cancer and their families for:

  • Participating in the clinical studies that enabled TUKYSA to be approved by the US Food and Drug Administration (FDA)
  • Speaking about their experience and sharing their everyday hopes

Important Safety Information

What are the possible side effects of TUKYSA?
TUKYSA may cause serious side effects, including:
  • Diarrhea (watery, loose, or frequent stools) is common and can sometimes be severe. Tell your healthcare provider if you have a change in your bowel movements or severe diarrhea. Severe diarrhea can cause a loss of too much body fluid (dehydration), low blood pressure, kidney problems, and death. Your healthcare provider may prescribe medicines to treat your diarrhea during treatment with TUKYSA.
  • Liver Problems, including severe cases. Your healthcare provider will test your blood to check your liver function before starting and every 3 weeks during treatment with TUKYSA, or as needed. Tell your healthcare provider right away if you have any signs and symptoms of liver problems including itching, yellowing of the skin or eyes, dark or brown urine (tea-colored), pain or discomfort in the right upper stomach area (abdomen), feeling very tired, decreased appetite, or bleeding or bruising more easily than normal.
The most common side effects of TUKYSA:
  • diarrhea
  • rash, redness, pain, swelling, or blisters on the palms of your hands or soles of your feet
  • nausea
  • tiredness
  • increased liver function blood tests
  • vomiting
  • mouth sores (stomatitis)
  • decreased appetite
  • stomach-area (abdomen) pain
  • headache
  • a low number of red blood cells (anemia)
  • rash

Your healthcare provider may change your dose of TUKYSA, temporarily stop, or permanently stop treatment with TUKYSA if you have certain side effects.

TUKYSA may cause fertility problems in males and females, which may affect the ability to have children. Talk to your healthcare provider if you have concerns about fertility.

These are not all the possible side effects of TUKYSA. Discuss side effects with your healthcare provider. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/Safety/MedWatch or call 1-800-FDA-1088.

What should I tell my healthcare provider before taking TUKYSA?

Before taking TUKYSA, tell your healthcare provider about all of your medical conditions, including if you:

  • have liver problems.
  • are pregnant or plan to get pregnant. TUKYSA can harm your unborn baby.

    Females who are able to become pregnant: Your healthcare provider will do a pregnancy test before you start taking TUKYSA. Use effective birth control (contraception) during TUKYSA treatment and for at least 1 week after the last dose of TUKYSA. Tell your healthcare provider right away if you become pregnant or think you may be pregnant during treatment with TUKYSA.

    Males with a female partner who can get pregnant: Use effective birth control during TUKYSA treatment and for at least 1 week after the last dose of TUKYSA.

  • are breastfeeding (nursing) or plan to breastfeed. Do not breastfeed during treatment with TUKYSA and for at least 1 week after the last dose of TUKYSA.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. TUKYSA may affect the way your other medicines work, and other medicines may affect the way TUKYSA works. Keep a list of all the medicines you take and show it to your healthcare provider and pharmacist every time you get a new medicine.

Indication
What is TUKYSA?

TUKYSA is a prescription medicine used with the medicines trastuzumab and capecitabine to treat adults with human epidermal growth factor receptor-2 (HER2) positive breast cancer that has spread to other parts of the body such as the brain (metastatic), or that cannot be removed by surgery, and who have received one or more anti-HER2 breast cancer treatments.

It is not known if TUKYSA is safe and effective in children.

Please see Important Facts about TUKYSA.