Indication: TUKYSA is a prescription medicine used with the medicines trastuzumab and capecitabine to treat adults with human epidermal growth factor receptor-2 (HER2) positive breast cancer that has spread to other parts of the body such as the brain (metastatic), or that cannot be removed by surgery, and who have received one or more anti-HER2 breast cancer treatments. It is not known if TUKYSA is safe and effective in children.

TUKYSA™ (tucatinib) tablets
TUKYSA™ (tucatinib) tablets
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TUKYSA Resources and Support

Take a look at the resources and support that are available to help you throughout treatment.

TUKYSA Brochure

Is your guide to treatment and what you can expect from TUKYSA, including possible side effects

TUKYSA Treatment Tracker

Helps you keep track of your dosing plan and take notes about how you are feeling

TUKYSA Treatment Tracker Calendar Pages

Use these additional calendar pages to help you stay on your dosing plan

Frequently Asked Questions

Get answers to frequently asked questions (FAQs) about TUKYSA.

What is TUKYSA?

TUKYSA is a prescription medicine used with the medicines trastuzumab and capecitabine to treat adults with human epidermal growth factor receptor-2 (HER2) positive breast cancer that has spread to other parts of the body such as the brain (metastatic), or that cannot be removed by surgery, and who have received one or more anti-HER2 breast cancer treatments. It is not known if TUKYSA is safe and effective in children. Learn more about TUKYSA.

Could TUKYSA be right for me?

TUKYSA was studied in 612 people with HER2+ metastatic breast cancer that had spread (metastasized) to other parts of the body in a clinical trial called HER2CLIMB. These people had been treated before with HERCEPTIN® (trastuzumab), PERJETA® (pertuzumab), and KADCYLA® (trastuzumab emtansine).

In HER2CLIMB, people were either given:

  • TUKYSA + trastuzumab + XELODA® (capecitabine)
  • Trastuzumab + capecitabine alone

What are the most common side effects seen with TUKYSA?

The most common side effects with TUKYSA:

  • diarrhea
  • rash, redness, pain, swelling, or blisters on the palms of your hands or soles of your feet
  • nausea
  • tiredness
  • increased liver function blood tests
  • vomiting
  • mouth sores (stomatitis)
  • decreased appetite
  • stomach-area (abdomen) pain
  • headache
  • a low number of red blood cells (anemia)
  • rash

These are not all the possible side effects of TUKYSA, and you may also get side effects from the other medicines taken with TUKYSA.

Talk to your healthcare provider about any side effects that bother you or do not go away. Learn more about possible side effects of treatment.

Has TUKYSA been evaluated in people with HER2+ metastatic breast cancer that has spread to the brain?

Yes. Nearly half of all people in HER2CLIMB—48% (291 out of 612)—had brain metastases. This included people with untreated and treated brain metastases that were stable or progressing since their last treatment. Learn more about treatment with TUKYSA.

Do I need tests with TUKYSA?

Your healthcare provider will test your blood to check your liver function before and every 3 weeks during treatment with TUKYSA, or as needed. These tests may be performed when you go in for your trastuzumab treatment. Based on the test results, your healthcare provider may adjust your dose, or temporarily or permanently stop treatment with TUKYSA.

If you are a female who can become pregnant, your healthcare provider will do a pregnancy test before starting TUKYSA.

I make plans beacuse it keeps me looking forward - Sharon Living with HER2+ MBC' I make plans beacuse it keeps me looking forward - Sharon Living with HER2+ MBC'

Advocacy Groups

There are many local, community, and national advocacy organizations available to help support people with breast cancer and their families. They each offer a range of services, including education, counseling, and financial assistance to help pay for the cost of treatment. There are also groups that offer legal services and employment advice.

Please note that the information that follows has been provided by each of the listed organizations. Seattle Genetics is not responsible for their content, and inclusion on this website is not intended as an endorsement of the organization or the services offered.

Education

BreastCancer.org
Dedicated to providing the most reliable, complete, and up-to-date information about breast cancer.
FORCE (Facing Our Risk of Cancer Empowered)
Provides support, education, and awareness to help those facing a range of hereditary and related cancers know their healthcare options and make informed decisions.
Living Beyond Breast Cancer (LBBC)
Delivers trusted medical and psychosocial information on early stage and metastatic breast cancer and connects individuals with a caring community of support.
Sisters Network® Inc. (SNI)
The only national African American breast cancer survivorship organization in the United States and a leading voice in the fight against breast cancer in the African American community.
Tigerlily Foundation
A national breast cancer foundation that provides education, awareness, advocacy, and hands-on support to young women (15-45)—before, during, and after breast cancer, as well as endeavoring to end health disparities of age, stage, and color.
Young Survival Coalition (YSC)
Strengthens the community, addresses the unique needs, amplifies the voice, and improves the quality of life of young adults affected by breast cancer.

Support

CANCERCare
CancerCare provides free professional support services and information to help people manage the emotional, practical, and financial challenges of cancer.
Cancer Support Community
The Cancer Support Community (CSC), including its Gilda’s Club affiliates, is a global non-profit network delivering cutting-edge research, providing free support services to patients and families—in person, over the phone and online, and leading policy solutions.
Leslie’s Week
A stage 4 metastatic breast cancer nonprofit that provides vacations away from cancer for stage 4 breast cancer women and their families.
SHARE
Educates, supports, and empowers women affected by breast, ovarian, or metastatic breast cancer, with a special focus on medically underserved communities.
Sharsheret
Sharsheret, Hebrew for chain, is the only national organization supporting Jewish women and families, and those of all backgrounds, who are facing breast and ovarian cancer or are at an increased genetic risk.
Susan G. Komen
Susan G. Komen’s mission is to save lives by meeting the most critical needs in our communities and investing in breakthrough research to prevent and cure breast cancer.

Research

BreastCancerTrials.org
A nonprofit service that encourages individuals affected by breast cancer to consider clinical trials as a routine option for care, by helping people interested in studies to learn about and find trials that are right for them.
Dr. Susan Love Foundation
Performs and facilitates innovative and collaborative research while translating science to engage the public as informed partners.
METAvivor
Dedicated to advancing research for those diagnosed with metastatic stage 4 breast cancer. The organization funds vital research to help improve the longevity and quality of life for MBC patients. METAvivor also provides support for those living with MBC as well as education, advocacy, and awareness.

For additional resources that educate and support metastatic breast cancer patients, please visit the Metastatic Breast Cancer Alliance to learn about their member network of breast cancer organizations.

Important Safety Information

What are the possible side effects of TUKYSA?
TUKYSA may cause serious side effects, including:
  • Diarrhea (watery, loose, or frequent stools) is common and can sometimes be severe. Tell your healthcare provider if you have a change in your bowel movements or severe diarrhea. Severe diarrhea can cause a loss of too much body fluid (dehydration), low blood pressure, kidney problems, and death. Your healthcare provider may prescribe medicines to treat your diarrhea during treatment with TUKYSA.
  • Liver Problems, including severe cases. Your healthcare provider will test your blood to check your liver function before starting and every 3 weeks during treatment with TUKYSA, or as needed. Tell your healthcare provider right away if you have any signs and symptoms of liver problems including itching, yellowing of the skin or eyes, dark or brown urine (tea-colored), pain or discomfort in the right upper stomach area (abdomen), feeling very tired, decreased appetite, or bleeding or bruising more easily than normal.
The most common side effects of TUKYSA:
  • diarrhea
  • rash, redness, pain, swelling, or blisters on the palms of your hands or soles of your feet
  • nausea
  • tiredness
  • increased liver function blood tests
  • vomiting
  • mouth sores (stomatitis)
  • decreased appetite
  • stomach-area (abdomen) pain
  • headache
  • a low number of red blood cells (anemia)
  • rash

Your healthcare provider may change your dose of TUKYSA, temporarily stop, or permanently stop treatment with TUKYSA if you have certain side effects.

TUKYSA may cause fertility problems in males and females, which may affect the ability to have children. Talk to your healthcare provider if you have concerns about fertility.

These are not all the possible side effects of TUKYSA. Discuss side effects with your healthcare provider. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/Safety/MedWatch or call 1-800-FDA-1088.

What should I tell my healthcare provider before taking TUKYSA?

Before taking TUKYSA, tell your healthcare provider about all of your medical conditions, including if you:

  • have liver problems.
  • are pregnant or plan to get pregnant. TUKYSA can harm your unborn baby.

    Females who are able to become pregnant: Your healthcare provider will do a pregnancy test before you start taking TUKYSA. Use effective birth control (contraception) during TUKYSA treatment and for at least 1 week after the last dose of TUKYSA. Tell your healthcare provider right away if you become pregnant or think you may be pregnant during treatment with TUKYSA.

    Males with a female partner who can get pregnant: Use effective birth control during TUKYSA treatment and for at least 1 week after the last dose of TUKYSA.

  • are breastfeeding (nursing) or plan to breastfeed. Do not breastfeed during treatment with TUKYSA and for at least 1 week after the last dose of TUKYSA.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. TUKYSA may affect the way your other medicines work, and other medicines may affect the way TUKYSA works. Keep a list of all the medicines you take and show it to your healthcare provider and pharmacist every time you get a new medicine.

Indication
What is TUKYSA?

TUKYSA is a prescription medicine used with the medicines trastuzumab and capecitabine to treat adults with human epidermal growth factor receptor-2 (HER2) positive breast cancer that has spread to other parts of the body such as the brain (metastatic), or that cannot be removed by surgery, and who have received one or more anti-HER2 breast cancer treatments.

It is not known if TUKYSA is safe and effective in children.

Please see Important Facts about TUKYSA.